Product Description
Lupisit GM 50mg/2mg/1000mg Tablet is a triple combination medicine containing Glimepiride (2mg), Metformin (1000mg), and Sitagliptin (50mg). It is prescribed for the treatment of type 2 diabetes mellitus when single or dual therapy is not enough to control blood sugar. The three ingredients work together to improve insulin release, reduce liver sugar production, and increase the body’s sensitivity to insulin.

Benefits
• Provides stronger control of blood sugar levels in type 2 diabetes
• Glimepiride stimulates the pancreas to release more insulin
• Metformin decreases glucose production in the liver and improves insulin sensitivity
• Sitagliptin enhances natural insulin release after meals and lowers excess sugar
• Helps lower the risk of diabetes-related complications such as kidney, eye, and nerve damage

Side Effects
• Low blood sugar (hypoglycemia), especially if meals are missed
• Stomach upset, nausea, diarrhea, or abdominal discomfort
• Headache, dizziness, or tiredness may occur in some patients
• Rarely, allergic skin reactions or inflammation of the pancreas may happen
• Lactic acidosis is a rare but serious side effect linked to metformin

How to Use
• Take exactly as directed by your doctor
• Swallow the tablet whole with water, preferably after meals
• Try to take at the same time each day for consistent sugar control
• Do not stop treatment suddenly without consulting your doctor

What to Avoid
• Avoid alcohol, as it can increase the risk of low blood sugar and lactic acidosis
• Do not take more than the prescribed dose
• Avoid skipping meals to reduce the chance of hypoglycemia
• Not suitable for type 1 diabetes or diabetic ketoacidosis

Precautions
• Inform your doctor if you have kidney, liver, or heart problems before starting
• Regular monitoring of blood sugar, kidney function, and liver enzymes may be required
• Elderly patients need careful monitoring due to higher risk of low sugar levels
• Pregnant and breastfeeding women should use only under medical supervision
• Seek medical help immediately if you experience severe weakness, persistent vomiting, abdominal pain, or yellowing of skin and eyes