Sitapride M 50/500 mg Tablet – Comprehensive Overview
Product Introduction

Sitapride M 50/500 mg Tablet is a combination antidiabetic medication used to manage Type 2 Diabetes Mellitus (T2DM). Type 2 diabetes occurs when the body either does not produce enough insulin or is unable to use insulin effectively. It may also develop due to excessive glucagon production.

This medication helps control blood sugar levels, reducing the risk of serious diabetes complications, including kidney damage, nerve damage, vision loss (retinopathy), and cardiovascular problems.

Composition

Sitagliptin 50 mg – DPP-4 inhibitor

Metformin 500 mg – Biguanide

Form: Tablet
Category: Antidiabetic combination therapy

Mechanism of Action

Sitapride M 50/500 mg Tablet works through two complementary mechanisms:

Sitagliptin:

Stimulates the pancreas to produce more insulin

Reduces glucagon production in the liver

Helps regulate blood sugar levels after meals

Metformin:

Reduces glucose production by the liver

Slows glucose absorption from the intestines

Improves insulin sensitivity in muscles and tissues

Together, they control blood glucose levels effectively, especially post-meal spikes.

Indications / Uses

Primary Use: Management of Type 2 Diabetes Mellitus

Detailed Benefits:

Glycemic Control: Enhances insulin sensitivity and reduces hepatic glucose output

Weight Management: May assist in controlling body weight

Prevention of Complications: Helps prevent retinopathy, neuropathy, nephropathy, diabetic foot ulcers, and delayed wound healing

Dosage and Administration

Route: Oral

Recommended: Take with meals to avoid stomach upset

Frequency: Usually twice daily, as advised by the doctor

Instructions:

Swallow the tablet whole, do not crush, chew, or break

Take at the same time each day

Do not skip meals

Carry a quick source of sugar to prevent hypoglycemia

Note: Your doctor may adjust the dosage based on your blood sugar levels.

Side Effects

Common Side Effects:

Hypoglycemia (low blood sugar) – dizziness, sweating, hunger, dry mouth/skin

Nausea, diarrhea, stomach pain

Headache

Upper respiratory symptoms

Changes in taste

Serious but rare side effects:

Lactic acidosis (accumulation of lactic acid in blood)

Severe skin reaction (bullous pemphigoid)

Thyroid-stimulating hormone (TSH) suppression (requires annual monitoring)

Warnings and Precautions

Allergies: Avoid if allergic to Sitapride M 50/500 mg Tablet

Contraindications: Type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease

Heart Disease / Pregnancy / Breastfeeding: Inform your doctor

Drug Interactions: May interact with insulin or other diabetes medicines, increasing risk of hypoglycemia

Diagnostic Procedures: Stop the drug temporarily before X-ray contrast procedures

How to Use

Take with meals to minimize gastrointestinal discomfort

Swallow whole with water

Follow doctor’s instructions carefully

Maintain regular monitoring of blood sugar levels

Storage

Store in a cool, dry place away from sunlight

Keep out of reach of children

Temperature: 10–25ºC or below 30ºC

Diet and Lifestyle Advice

Eat starchy vegetables, whole grains, proteins, and fibre-rich foods

Maintain regular meal intervals

Monitor blood sugar regularly

Keep quick sugar handy for hypoglycemia

Exercise: ≥150 min moderate-intensity or 75 min high-intensity weekly

Gradual weight reduction to maintain healthy BMI (18.5–24.9)

Limit saturated fats; choose omega-3 rich oils for cooking

Reduce stress using mindfulness or relaxation techniques

Use low-fat dairy products

Maintain normal blood pressure (~140/90 mmHg) to lower cardiovascular risk

Summary

Sitapride M 50/500 mg Tablet is a dual-action antidiabetic medicine combining Sitagliptin and Metformin to:

Control fasting and post-meal blood sugar levels

Prevent long-term complications of diabetes

Support weight and metabolic health

Require adherence to diet, exercise, and regular monitoring

If you want, I can also create a comparison chart of all Sitapride / Sitanorm / Sitapride-M tablets showing composition, dosage, and key precautions, which makes it easy to understand differences between these diabetes medicines.