3% Normal Saline (3% Sodium Chloride) 100 mL is a sterile hypertonic saline solution used in hospitals and critical care settings to correct severe hyponatremia (low blood sodium) and to help manage elevated intracranial pressure (ICP) in neurological conditions.
Product Description
3% NS is a hypertonic crystalloid IV solution containing 3 grams of sodium chloride per 100 mL of water. This higher sodium concentration (513 mEq/L of Na⁺ and Cl⁻) increases the osmolarity of blood, drawing water out from cells into the bloodstream. The solution is clear, colorless, sterile, and non-pyrogenic, intended for intravenous use under medical supervision.
Composition (per 100 mL)
Sodium Chloride: 3 g
Water for Injection: q.s. to 100 mL
Sodium: 513 mEq/L
Chloride: 513 mEq/L
Osmolarity: ~1026 mOsm/L
pH: 4.5–7.0
Indications
Severe symptomatic hyponatremia (serum Na⁺ <120 mmol/L)
Acute neurological conditions such as traumatic brain injury, cerebral edema, or stroke to reduce ICP
Cerebral salt-wasting syndrome
Postoperative or neurosurgical patients with increased intracranial pressure
Administration
Administered intravenously, typically via a central vein (though 100 mL doses may sometimes be given peripherally with caution).
Infusion rates must be carefully controlled to prevent rapid sodium correction, which can cause osmotic demyelination syndrome (ODS).
Regular monitoring of serum sodium and neurological status is mandatory.
Warnings & Precautions
Use only under strict medical supervision.
Do not use for routine fluid replacement.
Avoid rapid infusion, as overcorrection of hyponatremia may lead to serious neurological complications.
Caution in patients with heart failure, renal impairment, or hypernatremia.
Packaging
Usually supplied in 100 mL, 250 mL, or 500 mL sterile plastic bottles or infusion bags.
Single-use only; discard any unused portion.
In short, 3% NS (100 mL) is a concentrated saline formulation used primarily in emergency or critical care to rapidly raise serum sodium or reduce brain swelling—administered with close monitoring in hospital settings.



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