clavikan 625 tablet’1*10

Overview

Amoxicillin and Clavulanic Acid is a broad-spectrum antibiotic combination used to treat various bacterial infections.

• Amoxicillin kills bacteria by interfering with cell wall synthesis.

• Clavulanic Acid inhibits bacterial enzymes (β-lactamases) that normally break down amoxicillin, allowing it to remain active for longer and act against more resistant bacteria.

together, they provide enhanced protection against a wider range of bacterial infections than amoxicillin alone.

Uses

This combination is used to treat a variety of bacterial infections, including:

• Respiratory tract infections: pneumonia, bronchitis, sinusitis

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Gastrointestinal infections: diarrhea, enteritis

• Bone and joint infections: osteomyelitis, septic arthritis

• Bloodstream infections: sepsis, endocarditis

Directions for Use

• Take this medicine as directed by your doctor.

• Usually taken every 8–12 hours with a meal to reduce stomach upset.

• Swallow whole with water—do not crush or chew.

• Complete the full prescribed course even if you feel better early.

Common Side Effects

Most side effects are mild and temporary:

• Nausea or vomiting

• Diarrhea

• Stomach discomfort

• Headache or dizziness

• Skin rash or itching

• Loss of appetite

• Vaginal itching or discharge

• Fatigue or weakness

• Taste changes

Serious (but rare) side effects:

• Allergic reactions (swelling, difficulty breathing, hives)

• Jaundice (yellowing of skin/eyes)

• Seizures (rare)

• Liver or kidney issues

• Blood disorders (low red or white cells, platelets)

Warnings

Before taking this medicine, inform your doctor if you have:

• Allergy to penicillin or cephalosporins

• Liver or kidney disease

• History of antibiotic-related diarrhea

• Blood disorders

⚠️ Avoid if: You are also taking tetracycline antibiotics.
🚫 Do not skip doses or stop early — this can cause infection relapse or resistance.

Drug Interactions

• Warfarin: May increase bleeding risk.

• Methotrexate: Can increase toxicity.

• Probenecid: Raises amoxicillin levels.

• Oral contraceptives: May reduce effectiveness.

• Tetracyclines: May decrease antibiotic effect.

• Antacids: Reduce absorption — take 2 hours apart.

Food interactions:

• Avoid dairy products (milk, cheese, yogurt) and iron/zinc supplements near dose times — they can reduce absorption.

Disease Interactions

• Liver disease: May increase liver injury risk.

• Kidney disease: May require dose adjustment.

• Blood disorders: Monitor blood counts closely.

Contraindications

• Do not consume alcohol — may increase stomach irritation or drowsiness.

• Pregnancy: Use only if clearly needed (doctor’s advice).

• Breastfeeding: Small amounts pass into milk; consult your doctor.

Missed Dose

• Take as soon as you remember.

• If it’s near your next dose, skip the missed one — don’t double up.

Lifestyle Advice

• Stay hydrated and eat balanced meals.

• Avoid alcohol and quit smoking.

• Exercise at least 30 minutes daily (150 minutes per week).

Storage

• Store at room temperature (below 25 °C).

• Keep away from heat, moisture, and sunlight.

• Do not refrigerate.