S-750 Tablets

The S-750 Tablet is an antibiotic medication containing Sultamicillin 750 mg, a combination of Ampicillin and Sulbactam. This combination enhances the efficacy of Ampicillin by inhibiting beta-lactamase enzymes produced by bacteria, thereby broadening its spectrum of activity against various bacterial infections.

Composition

• Sultamicillin (as 750 mg tablet): Upon administration, Sultamicillin is hydrolyzed to release Ampicillin and Sulbactam in the body.

Uses
S-750 Tablet is prescribed for the treatment of a wide range of bacterial infections, including:

• Respiratory tract infections (e.g., pneumonia, bronchitis)

• Urinary tract infections (e.g., cystitis, pyelonephritis)

• Skin and soft tissue infections (e.g., cellulitis, abscesses)

• Ear infections (e.g., otitis media)

• Gonorrhea

• Post-operative infections

• Gynecological infections

• Intra-abdominal infections
  It is effective against beta-lactamase-producing organisms, which are resistant to many other antibiotics.

Dosage and Administration

• The typical dosage for adults and children weighing over 30 kg is 750 mg twice daily.

• The tablet should be swallowed whole with a glass of water.

• It can be taken with or without food.

• The duration of therapy depends on the type and severity of the infection but typically ranges from 5 to 14 days.

• For uncomplicated gonorrhea, a single dose of 2.25 g (three 750 mg tablets) may be administered, often in combination with probenecid 1.0 g to prolong the plasma concentration of Sulbactam and Ampicillin.

Mechanism of Action

• Ampicillin: Inhibits bacterial cell wall synthesis, leading to cell lysis and death.

• Sulbactam: Inhibits beta-lactamase enzymes produced by bacteria, preventing the degradation of Ampicillin and extending its antibacterial activity.
  Together, they provide a synergistic effect, enhancing the antibiotic’s efficacy against resistant bacteria.

Common Side Effects

• Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal pain.

• Skin reactions: rash, itching.

• Hematological effects: rare cases of thrombocytopenia (low platelet count), leukopenia (low white blood cell count).

• Liver enzyme alterations: transient increases in liver enzymes.

• Superinfections: overgrowth of non-susceptible organisms, including fungi.
  Most side effects are mild and resolve upon discontinuation of the medication.

Precautions and Warnings

• Allergy: Contraindicated in patients with a known allergy to penicillin or beta-lactam antibiotics.

• Liver and Kidney Function: Use with caution in patients with hepatic or renal impairment; dosage adjustments may be necessary.

• Pregnancy and Breastfeeding: Generally considered safe during pregnancy and breastfeeding when prescribed by a healthcare provider.

• Drug Interactions: May interact with other medications; inform your healthcare provider of all drugs you are taking.

Storage

• Store at room temperature, away from moisture and heat.

• Keep out of reach of children.

Missed Dose

• If a dose is missed, take it as soon as you remember.

• If it’s almost time for the next dose, skip the missed dose; do not double the dose to make up for a missed one.

Overdose

• Symptoms of overdose may include severe gastrointestinal disturbances and allergic reactions.

• Seek immediate medical attention if an overdose is suspected.