Upnuron-D 75/30 Capsule 10’s is a combination medicine used to manage and relieve nerve-related pain, particularly in conditions like diabetic neuropathy and fibromyalgia. Neuropathic pain arises when the nerves become damaged or function abnormally, leading to sensations such as burning, tingling, or sharp shooting pain. Diabetic neuropathy often affects the legs, thighs, or buttocks, while fibromyalgia causes widespread pain, tiredness, and disturbed sleep. This capsule helps reduce discomfort, restore nerve function, and improve the overall quality of life.
Composition and Nature of the Medicine
Upnuron-D 75/30 Capsule 10’s contains two key active ingredients – Pregabalin and Duloxetine.
• Pregabalin belongs to the anticonvulsant group of medicines and works by calming hyperactive nerve signals, reducing pain transmission, and preventing abnormal nerve activity.
• Duloxetine is a serotonin and norepinephrine reuptake inhibitor that increases the levels of mood-regulating brain chemicals, helping the body manage pain and emotional stress effectively.
Medicinal Benefits
• Provides effective relief from nerve pain caused by diabetes-related nerve damage.
• Reduces symptoms of fibromyalgia, including body pain, muscle tenderness, and fatigue.
• Helps calm overactive nerves, promoting better nerve signal transmission.
• Improves sleep quality and reduces restlessness caused by chronic pain.
• Enhances emotional well-being by stabilizing mood and reducing stress.
How Upnuron-D 75/30 Capsule 10’s Works
Upnuron-D 75/30 Capsule 10’s works through a dual mechanism. Pregabalin helps relax overactive nerve cells, preventing pain signals from being transmitted excessively to the brain. Duloxetine enhances the levels of serotonin and norepinephrine, which are natural pain-relieving and mood-balancing chemicals. Together, they help reduce nerve pain, improve nerve function, and bring comfort to individuals suffering from chronic neuropathic conditions.
Directions for Use
• Take Upnuron-D 75/30 Capsule 10’s with or without food as advised by your doctor.
• Swallow the capsule whole with a glass of water; do not chew or crush it.
• Take it at the same time every day for consistent therapeutic effect.
• Follow your doctor’s dosage instructions carefully and avoid skipping doses.
Possible Side Effects
Some mild and temporary side effects may occur, such as:
• Dizziness or sleepiness
• Headache or confusion
• Dry mouth or nausea
• Constipation or mild stomach upset
• Increased sweating or loss of appetite
• Swelling of feet or ankles in rare cases
These usually subside on their own. If any symptom persists or becomes severe, contact your doctor promptly.
What to Avoid While Using This Medicine
• Avoid alcohol or sedative drugs as they may enhance dizziness or drowsiness.
• Do not drive or operate heavy machinery if you feel sleepy or less alert.
• Avoid stopping the medicine suddenly; it should be discontinued gradually under medical advice.
• Refrain from taking other pain-relief medicines or antidepressants without consulting your doctor.
Safety Advice and Precautions
• Do not take this medicine if you are allergic to Pregabalin or Duloxetine.
• Inform your doctor if you have liver, kidney, or heart disease before starting the treatment.
• Pregnant and breastfeeding women should use this medicine only under medical supervision.
• This medicine is not recommended for individuals below eighteen years of age.
• Caution is advised in patients with bipolar disorder, depression, or glaucoma.
• Avoid combining it with alcohol, as it may increase the risk of dizziness and drowsiness.
Storage Information
• Store the capsules in a cool and dry place, away from moisture and direct sunlight.
• Keep out of reach of children and pets.
• Maintain storage temperature between ten to twenty-five degrees Celsius.
Lifestyle and Dietary Tips
• Eat foods rich in vitamins B and D to support nerve health.
• Include fresh fruits, vegetables, and whole grains in your daily diet.
• Avoid excessive caffeine or smoking, as they can worsen nerve discomfort.
• Engage in light physical exercises, yoga, or walking to improve circulation.
• Practice relaxation techniques such as deep breathing or meditation to ease tension and promote better sleep.



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