Zidavi Infusion

Introduction
Zidavi Infusion is a combination antibiotic used to treat serious bacterial infections of the urinary tract, respiratory system, abdomen, and blood. It is especially effective against difficult-to-treat and drug-resistant infections caused by Gram-negative bacteria.

The medicine contains two active components:

• Ceftazidime – prevents bacteria from forming a protective cell wall, which is vital for their survival.

• Avibactam – reduces bacterial resistance by blocking enzymes that deactivate antibiotics, thereby enhancing the effect of Ceftazidime.

Together, they work to control and eliminate severe bacterial infections.

Uses of Zidavi Infusion

• Complicated urinary tract infections (including pyelonephritis)

• Complicated intra-abdominal infections

• Hospital-acquired and ventilator-associated pneumonia

• Bloodstream infections (bacteremia) caused by multidrug-resistant bacteria

• Other severe Gram-negative bacterial infections

Benefits

• Broad-spectrum coverage against aerobic and anaerobic bacteria

• Active against resistant strains where other antibiotics may fail

• Effective in treating infections that are difficult to manage in hospital settings

How It Works

Ceftazidime disrupts bacterial cell wall formation, leading to the death of bacteria. Avibactam prevents antibiotic resistance by inhibiting enzymes (beta-lactamases) that normally destroy antibiotics. This combination makes the bacteria more sensitive and improves treatment success.

Directions for Use

• Administered only by a healthcare professional via intravenous infusion.

• Do not self-administer.

• Follow your doctor’s prescribed dose and treatment schedule.

Possible Side Effects

Most side effects are temporary and subside as your body adjusts to treatment. Common ones include:

• Redness, swelling, or pain at injection site

• Nausea, vomiting, or diarrhea

• Dizziness

• Itching or rash

• Abnormal liver function tests

• Fever or signs of inflammation

• Rarely, very serious reactions such as Stevens-Johnson syndrome

Seek medical attention if side effects are severe or persistent.

Warnings & Precautions

• Inform your doctor if you have kidney or liver problems, diabetes, or a history of antibiotic allergies.

• Use with caution in patients with Clostridium difficile-associated diarrhea.

• Pregnant or breastfeeding women should take Zidavi Infusion only if prescribed.

• May cause dizziness—avoid driving unless you feel fully alert.

• Complete the full treatment course to prevent recurrence or resistance.

• Inform your doctor if you are on a controlled sodium diet, taking diuretics, or receiving vaccinations.

Drug Interactions

• May interact with certain antibiotics (e.g., Ceftizoxime).

• Should not be used with live cholera vaccines.

• Use caution with diuretics such as furosemide, as they may increase the risk of kidney problems.

Lifestyle & Dietary Advice

• Take probiotics or probiotic-rich foods (yogurt, kefir, sauerkraut, kimchi) after the course to restore gut health.

• Eat fiber-rich foods and whole grains to support digestion.

• Drink sufficient water throughout the day.

• Avoid alcohol as it may worsen side effects.

Storage

• Keep in a cool, dry place, away from sunlight.

• Store between 10°C to 25°C (below 30°C).

• Keep out of reach of children.

Safety Profile

• Alcohol: Interaction unknown; consult your doctor.

• Pregnancy & Breastfeeding: Use only if prescribed.

• Liver & Kidney: Dose adjustments may be required in patients with existing conditions.

• Children: Not recommended below 3 months of age.